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Rheolyse Hydrafine
Invisible Linked

Hydrafine

Resorbable medical device for the overall improvement of facial tissue quality. It works subcutaneously, supporting skin elasticity and turgor.

G′ · Elastic
30Pa
G″ · Viscous
22Pa
tan δ
0.73
02 Anatomical plane · Where it works

Mid and
superficial dermis.

Hydrafine works in the planes where skin lives on movement: it brings tissue quality, not structural volume. It works along the fine line without filling it: it follows it, hydrates it, restores its elasticity.

01Periocular linesMid dermis
02Perioral linesMid dermis
03Tissue quality · cheekSup. dermis
04Neck and décolletéMid dermis
05Back of the handsMid dermis
Model showing Hydrafine application areas: periocular lines, skin irregularities, barcode lines
03 Rheological profile · Hydrafine

Low G′,
high movement.

A deliberately soft, viscous gel: a restrained G′ that imposes no structure, and a high tan δ that spreads through the superficial planes without focal accumulation.

G
Elastic modulus
30Pa
10200
The gel's ability to resist deformation. A very low value: Hydrafine does not build volume, it distributes it.
G
Viscous modulus
22Pa
10140
A viscous component that dominates over volume. The gel flows, adapts and blends with the tissue.
tan δ
Viscoelastic coefficient
0.73
01
High. It indicates a predominantly viscous behaviour: maximum tissue integration, invisible to the touch.
G′ · Comparison
across the Rheolyse line
30
100
100
200
10
80
Hydrafine Sublimelip Dynamic Deeplift Restore 32 Puresense 64
04 Indications · Clinical applications

Five territories
of naturalness.

— 01

Periocular lines and crow's feet

Softens fine texture without filling, preserving the expressiveness of the gaze and eyelid movement.

— 02

Perioral lines and barcode lines

Corrects fine vertical lines, restoring tissue firmness to the upper lip without altering its profile.

— 03

Facial tissue quality

Hydrates and replenishes cheeks and temples on the superficial plane, for brighter, firmer skin.

— 04

Neck and décolleté

Restores elasticity and texture in the planes where skin is thinnest and movement is constant.

— 05

Back of the hands

Re-establishes the superficial moisture film of ageing hands, restoring quality without volume.

— 06

Cross-linked biorevitalisation

A bridge between biostimulation and fillers: a gel that hydrates like a biorevitaliser and persists like a filler.

05 Behaviour · How it behaves in tissue

Hydrafine does not rebuild, it accompanies. It integrates into the superficial planes without imposing support, restoring quality where quality is required, not volume.

— Integration

A low G′ combined with a high tan δ allows the gel to blend with the dermis without creating palpable discontinuities. Invisible to the touch.

— Duration

Controlled BDDE cross-linking offers an estimated persistence of 6 to 9 months, depending on the treated area and individual physiology.

— Reversibility

Non-animal sodium hyaluronate: fully hyaluronidase-sensitive, safe, and removable at any time.

06 Specifications · Technical data

Every number
is a decision.

Concentration, cross-linking, sterilisation filters: no parameter is left unexamined. Every choice answers to a required behaviour.

HA concentration
25 mg/ml cross-linked hyaluronic acid
Origin
Non-animal Streptococcus equi
Cross-linking agent
BDDE butanediol diglycidyl ether
Degree of cross-linking
Low for tissue invisibility
Syringe volume
1.1 ml pre-filled, sterile
Recommended needle
30G · 13 mm or 27G cannula
Local anaesthetic
Not included
pH
7.0 – 7.4 physiological
Osmolarity
280 – 320 mOsm/kg
Storage
2 – 25 °C protected from light
Classification
CE-marked medical device Class III
07 Protocol · Injection techniques

Three techniques,
one principle: the correct plane.

Technique A

Linear retrograde threading

30G needle · 13 mm · 20° angle

Small retrograde boluses along the line of the wrinkle. Estimated dose of 0.01–0.02 ml per injection, distributed evenly along the path.

Technique B

Serial micro-wheals

30G needle · 4 mm · intradermal

Micro-wheals of 0.02–0.03 ml on a 1 cm grid for tissue quality. Ideal for cheeks, neck and the back of the hands.

Injection depth

Target planes

Epidermis — no
Sup. dermis yes
Mid dermis target
Deep dermis rare
Hypodermis — no

— Protocol guidance is intended for licensed healthcare professionals. Always consult the full instructions for use.

08 Field of action · Outside and inside

The layer you do not see.

Hydrafine works at the subcutaneous level, integrating with the underlying tissue matrix. The quality perceived at the surface is the result of structural cohesion re-established in depth.

Inner layer: subcutaneous anatomy, muscle structure and adipose tissue where Hydrafine works
Outer layer: skin surface, visible tissue quality
09 Linked line · The other gels

Three companions
for different planes.

The full line

Hydrafine is a medical device.
Request professional access.

B2B sales contact Download the anatomical datasheet (PDF)
For licensed healthcare professionals only · Not for retail