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The Science
of Naturalness.

The aim of Rheolyse is to intervene with precision, guiding anatomical balance through a scientific approach oriented towards naturalness. Each formulation is developed from the rheological parameters — G', G'', tan δ — to deliver a response consistent with the treated plane, respecting tissue structure and dynamics.

— Rheological parameters
G' · G'' tan δ
— Gel characteristics
Cohesivity + Plasticity
— Complementary lines
2 Linked · Pure
— Certifications
3 ISO + CE
01 · Parameters G', G'' and tan δ

Three parameters.
One balance.

The rheological design of Rheolyse is oriented towards the behaviour of the gel in tissue. Rheology describes the response of hyaluronic acid once injected, in relation to the mechanical stresses of the face.

Each parameter is calibrated to work in balance with the others, because the naturalness of the result arises from the coherence between gel, tissue architecture and movement.

G' Elastic modulus Pa

G' expresses the elastic component of the gel — its ability to resist deformation and maintain its shape over time. A high G' provides greater structural support; a modulated G' allows the gel to support tissue without stiffening it. Clinically, G' determines how much the product supports and how closely it follows the anatomy.

G" Viscous modulus Pa

G'' describes the viscous component of the gel — its ability to flow and adapt under stress. An adequate G'' promotes diffusion within the tissue, improves the continuity of the result and reduces the risk of localised accumulation.

tan δ Ratio between G' and G'' dimensionless

Tan δ represents the balance between viscosity and elasticity. Lower values indicate more elastic behaviour; higher values, a greater viscous component. In Rheolyse gels, tan δ is designed to avoid extreme behaviour, favouring harmonious interaction with the tissue and a natural response to facial dynamics.

02 · Characteristics Cohesivity and plasticity

How the gel holds
and how it is shaped.

Beyond the rheological moduli, two characteristics define the clinical behaviour of the injected gel: its ability to remain cohesive over time and its ability to adapt to the practitioner's action during treatment.

Cohesivity Ability to remain cohesive after injection

A cohesive gel does not fragment or migrate; it integrates stably within the tissue planes. Clinically, cohesivity is essential for keeping the product in place and supporting an orderly, controllable result over time.

Plasticity Ability to change shape under the practitioner's action

A plastic gel is easily shaped: it adapts to the patient's anatomical morphology and retains the shape achieved. This parameter allows a progressive, physiological correction, without rigidity.

03 · Balance Balance between G' and G''

High G': return.
High G'': adaptation.

The Rheolyse rheological framework considers the ratio between the two components of the gel. When G' prevails, the gel favours structural return and support; when G'' prevails, the gel favours dynamic adaptation and tissue diffusion.

G'+ G"
Return · structural support

The gel maintains its shape over time, supports the tissue and works as an element of volumetric architecture.

G'= G"=
Balance · harmonious interaction

The two components are balanced. The gel supports and at the same time follows facial dynamics, without extreme behaviour.

G' G"+
Adaptation · tissue diffusion

The gel flows, adapts and distributes itself. It works as an element of physiological integration and progressive stimulation.

04 · Two principles Invisible Linked and Invisible Pure

Two lines.
One method.

Rheolyse is organised into two complementary lines, designed to address different clinical needs yet united by the same design principle: choosing the behaviour of the product before its volume, to preserve balance, harmony and naturalness.

— Invisible Linked

Cross-linked hyaluronic acid.

Four formulations (Hydrafine, Sublimelip, Dynamic, Deeplift) designed for harmonious integration across the different anatomical planes, with a rheological profile oriented towards naturalness and dynamic control.

Designed to accompany movement and expressiveness, these products promote tissue continuity and proportion, maintaining coherence between structure and function.

4 products · superficial to deep planes
— Invisible Pure

Pure, non-cross-linked hyaluronic acid.

Two formulations (Restore 32, Puresense 64) based on pure hyaluronic acid, developed to provide structural response and precision in treatments requiring greater support.

High purity and a defined mechanical behaviour allow accurate control of the result in the anatomical planes with the highest functional demand, respecting the morphology of the face.

2 products · session-based protocol
05 · Comparative data Summary technical data of the six fillers

The catalogue,
on a single sheet.

Rheological parameters and product specifications. For full protocols and clinical indications, please refer to the instructions for use and the technical brochure for each line.

Product Line HA G' [Pa] G'' [Pa] tan δ Packaging Duration · Protocol
Hydrafine— tissue quality Linked 25 mg/ml · 1.1 ml 30 10 0.33 27G·19 + 30G·13 4 — 5 months
Sublimelip— lips Linked 25 mg/ml · 1 ml 100 20 0.20 27G·19 + 27G·13 6 — 7 months
Dynamic— mid planes Linked 25 mg/ml · 1 ml 100 20 0.20 27G·19 + 27G·13 7 — 9 months
Deeplift— deep planes Linked 25 mg/ml · 1 ml 200 40 0.20 27G·19 + 27G·13 9 — 11 months
Restore 32— dermal hydration Pure 32 mg/2 ml 10 30 3.0 1 needle 30G · 4 mm 3 sessions · T+15d, T+45d
Puresense 64— deep support Pure 64 mg/2 ml 80 140 1.75 2 needles 30G · 13 mm 2nd session T+30d · maintenance every 4 months
06 · Cross-linking Control, not excess

Measured cross-linking.
Calibrated naturalness.

The cross-linking process, carried out at low temperature with long reaction times, allows precise control over the structure of the gel. This approach enables measured cross-linking, a reduction in residual chemical agent and the preservation of functional rheological properties.

The Invisible Linked line is formulated with cross-linked hyaluronic acid, calibrated for the different anatomical planes. The Invisible Pure line uses pure, linear, non-cross-linked hyaluronic acid, obtained by bacterial fermentation, for a physiological approach to treatment.

07 · Pure protocol Time as a therapeutic factor

Pure hyaluronic acid
works with the rhythms of the tissue.

The products of the Invisible Pure line form part of a structured clinical pathway in which time is an essential therapeutic factor. Clinical effectiveness requires respecting the intervals between sessions, continuity of treatment and consistent scheduling of the protocol.

Each session contributes to building a progressive, stable response. Unplanned variation of the intervals reduces the quality of the biological response.

08 · Certifications International standards and Made in Italy

International standards.
Entirely Italian production.

Rheolyse operates according to the highest international standards of quality, safety and sustainability. All products are made entirely in Italy, with direct control over every production phase.

ISO 9001:2015
Quality management

The international standard for quality management systems: it ensures controlled, traceable processes oriented towards continuous improvement.

ISO 13485:2016
Medical devices

The certification specific to quality management systems in the design, development and manufacture of medical devices.

ISO 14001:2015
Environmental management

The standard for controlling the environmental impact of production processes, safeguarding sustainability across the entire supply chain.

CE marking
European conformity

All Rheolyse devices comply with the safety and performance requirements for marketing within the European Union.