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Rheolyse Puresense 64
Invisible Pure

Puresense 64

Restores support to the deep tissue and improves skin quality in areas affected by volume loss.

HA · Pure
64mg/2 ml
G′ · Elastic
80Pa
tan δ
1.75

Hypodermis
and deep dermis.

Puresense 64 does not create volume: it stimulates the tissue to rebuild itself. Deposited in the hypodermis and the deep dermis, it activates the response of fibroblasts and adipocytes, re-establishing natural support where age, weight loss or laxity have reduced density and firmness.

01Deep cheekboneHypodermis
02Temporal hollowHypodermis
03Pre-auricular · cheekDeep dermis
04Lower third · jawlineHypodermis
05Peri-oral supportDeep dermis
Model showing Puresense 64 application areas

Non-cross-linked.
Non-reticulated.

Puresense 64 is not a volumising filler: it is linear hyaluronic acid at very high concentration — 64 mg/2 ml — not stabilised by BDDE. Its function is not structural, it is biological: to stimulate the endogenous production of collagen, elastin and HA.

HA
Concentration · pure HA
64mg/2 ml
3264
The highest concentration in the Rheolyse line. A dense biological deposit that feeds the fibroblasts and reactivates the matrix.
G
Elastic modulus · residual
80Pa
10200
A residual, non-cross-linked modulus, sufficient for an even deposit in the hypodermis. It does not support volume: it accompanies biostimulation.
t½
Physiological degradation
90days
30180
A programmed half-life. The gel is metabolised within three months, while the result grows with the tissue renewal it stimulates.
G′ · Comparison
across the Rheolyse line
30
100
100
200
10
80
Hydrafine Sublimelip Dynamic Deeplift Restore 32 Puresense 64

Six territories
of density.

— 01

Cheekbone biostimulation

Reactivates the hypodermic support of the deep cheekbone, restoring projection without adding exogenous volume.

— 02

Temporal hollow

Deposited in the temporal hypodermis, it reactivates the sub-fascial adipose tissue, reducing the skeletonised appearance.

— 03

Jawline and lower third

Re-establishes tone and support along the jawline without creating focal volume: a qualitative upgrade of the tissue.

— 04

Post weight loss

Reorganises the matrix in the areas where weight loss has reduced hypodermic density and skin firmness.

— 05

Diffuse skin laxity

Grid-pattern stimulation on the mid-to-lower third: progressive improvement in elasticity, dermal thickness and radiance.

— 06

Pre-filler preparation

Biostimulation preparatory to structural treatments: it improves the quality of the tissue bed before injecting cross-linked gels.

Puresense 64 does not fill, it reactivates. It leaves no volumetric trace: it leaves tissue better than it found it.

— Activation

The high concentration of linear HA stimulates the fibroblasts to synthesise type I and III collagen, elastin and endogenous hyaluronic acid over 4–8 weeks.

— Degradation

Complete physiological metabolisation in around 90 days. The gel disappears; the regenerated tissue remains. Optimal protocol: 3 sessions 30 days apart.

— Integration

Non-cross-linked, non-stabilised, fully bio-identical HA. No BDDE residue, no need for enzymatic reversal.

Every number
is a decision.

Concentration, purity, origin: no parameter is left unexamined. Every choice answers to a required behaviour.

HA concentration
64 mg/2 ml pure hyaluronic acid
Origin
Non-animal Streptococcus equi
Cross-linking
None linear HA, non-cross-linked
Molecular weight
1.8 – 2.2 MDa high molecular weight
Syringe volume
2.0 ml pre-filled, sterile
Recommended needle
27G · 25 mm or 25G cannula
Local anaesthetic
Not included
pH
7.0 – 7.4 physiological
Osmolarity
280 – 320 mOsm/kg
Storage
2 – 25 °C protected from light
Classification
CE-marked medical device Class III

Three techniques,
one principle: deep activation.

Technique A

Hypodermic fanning

25G cannula · 50 mm · sub-SMAS plane

Deep fanning with a cannula across the cheekbone and temple. Dose of 0.3–0.5 ml per area, deposited slowly to stimulate the adipocyte response.

Technique B

Bolus on bone

27G needle · 25 mm · periosteal

Point deposit in contact with the bone at zygomatic landmarks. Dose of 0.1–0.2 ml per point, for biostimulation of the sub-SMAS plane.

Injection depth

Target planes

Epidermis — no
Sup. dermis — no
Mid dermis — no
Deep dermis yes
Hypodermis target

— Protocol guidance is intended for licensed healthcare professionals. Always consult the full instructions for use.

08 Field of action · Outside and inside

The layer that restores support.

Puresense 64 works in the deep planes of the adipose tissue and within the supporting matrix. The improvement in skin quality visible at the surface is the result of the biological activation and structural reorganisation the product establishes in depth.

Inner layer: deep adipose tissue and supporting matrix where Puresense 64 works
Outer layer: skin quality and facial morphology

The more
superficial counterpart.

The full Pure line

Puresense 64 is a medical device.
Request professional access.

B2B sales contact Download the anatomical datasheet (PDF)
For licensed healthcare professionals only · Not for retail